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Electrophysiological studies in murine neuronal cultures and functional analyses in Caenorhabditis elegans revealed that the UNC13A variant causes a distinct dominant gain of function that is characterized by increased fusion propensity of synaptic vesicles, which leads to increased initial synaptic vesicle release probability and abnormal short.

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Munc13 proteins are essential regulators of neurotransmitter release at nerve cell synapses. They mediate the priming step that renders synaptic vesicles fusion-competent, and their genetic elimination causes a complete block of synaptic transmission..

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Personal norms have been shown to be important in the context of safer sex (van Empelen, Kok, Jansen, & Hoebe, 2001; van Kesteren, Hospers, van Empelen, van Breukelen, & Kok, 2007). Furthermore, anticipated affect for condom use and condom carrying was examined. The assumption underlying the predictive value of anticipated regret is that people.

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Background: Promotion of a healthy lifestyle for people with intellectual disabilities is important; however, the effectiveness of lifestyle change interventions is unclear. Aims: This research will examine the effectiveness of lifestyle change interventions for people with intellectual disabilities. Methods and Procedures: Randomized controlled trials (RCTs) of lifestyle change interventions.

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Dr. Francesco E. Michelassi is a neurologist in New York, New York. He received his medical degree from Weill Cornell Medicine and has been in practice between 3-5 years. Specialties Specialty.

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