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Sweat as a diagnostic biofluid Skin-interfaced microfluidic systems help assess health status and chemical exposure , , and Authors Info & Affiliations Science 23 Feb 2023 Vol 379, Issue 6634 pp. 760 - 761 DOI: 10.1126/science.abq5916 Eccrine sweat glands in the skin are key components of an ingenious system for evaporative cooling.

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Sweat, as a biofluid with the potential for noninvasive collection, provides profound insights into human health conditions, because it contains various chemicals and information to be utilized for the monitoring of well-being, stress levels, exercise, and nutrition.

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In the sweat detection, the fluorescence method is often used to measure Cl − whose content is the gold standard for diagnosing cystic fibrosis (CF). The Cl − concentration in the patient's sweat can be abnormally high (> 60 mmol/L). 16 Zhang et al. 17 reported a smartphone operated chloridometer for the first time. Fig. 2 shows a schematic of the system.

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The conductivity or admittance (resistance or impedance) of sweat is associated with the SSR and sweat electrolyte concentrations such that sweat and electrolyte loss can be calculated by measuring the conductivity of the collected sweat in the microchannel using electrodes. In 2016, Liu et al. proposed a prototype of a sweat conductivity sensor with a type of wrist watch.

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Flexible wearable sweat sensors allow continuous, real-time, noninvasive detection of sweat analytes, provide insight into human physiology at the molecular level, and have received significant.

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2.1. Sweat as a biofluid. Eccrine sweat sensing has been an underdeveloped area of research for wearable sensing until recent years. With the development of sensors with integrated sweat stimulation for continuous sweat access [18,19], and with multiplexed sensing arrays for in situ calibration of analyte measurements [3,20], sweat sensing is emerging as a technology capable of providing.

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1 Altmetric Explore all metrics Abstract Recent advances in the skin-interfaced wearable sweat sensors allow a personalized daily diagnosis and prognosis of the diseases in a form of a non-invasive, portable, and continuous monitoring system.

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Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers that reflect hydration state, fatigue.

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This review provides a comprehensive review of wearable sweat sensors and outlines state-of-the-art technologies and research that strive to bridge the gaps. Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward personalized healthcare. Advances in flexible electronics, materials science, and electrochemistry.

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Design and overview of the autonomous wearable biosensor technology. The flexible and disposable sensor patch consists of two carbachol-loaded iontophoresis electrodes, a multi-inlet microfluidic.

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Precise, real-time measurements of sweat dynamics (i.e., local sweating rate and local total sweat volume) and sweat biomarkers require wearable chemical systems capable of continuous capture and analysis of sweat and transmission of the resulting information locally to the user or remotely to health professionals (4, 5). A critical requirement for the broad adoption of such wearable systems.

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Bandodkar et al. 62 achieved in situ sweat sensing in 2013, using a whole body-washdown method since local sweat collection cannot fully reflect human sweat. For the procedure, the subject is.

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The increased use of CFTR modulators in the treatment of CF has highlighted the need for precise and accurate biomarkers to evaluate their efficacy.. Jeong I, Kim K, Sosnay PR, Cutting GR, et al.. Sweat test for cystic fibrosis: Wearable sweat sensor vs. standard laboratory test. J Cyst Fibros. (2018) 17:e35-e38. 10.1016/j.jcf.

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Skin*. Sweat. Wearable Electronic Devices*. Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward personalized healthcare. Advances in flexible electronics, materials science, and electrochemistry have spurred the development of wearable sweat sensors that enab..

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